millions treated for hypothyroidism at risk for lung cancer

A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Untreated hypothyroidism increases morbidity and mortality. In fact, it is the high levels of T4 that make them more susceptible to cancer. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Tokushima J Exp Med 1991, 38:2535. I honestly do not know. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Join the Patient & Caregiver Network. PMID: 23539727, [16] Alan R Gaby. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. I have posted the link now. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. I invite those interested to read it and perhaps we can have a discussion on this study. Maybe because they "treat" only with T4 and not T3? The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. Diagnosed 1/12 with lung cancer out of the blue. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Find how some diseases can be healed with alternative medicine, and share your experience with Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? I had doctor after doctor tell me it was in my head or I was menopausal. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. I cried with joy when I found out there was something really wrong with me. Non-ASPS articles which could be relevant. Angiology 2000, 51:S65S68. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Is so taking anti oxidants might be an idea. In my view the paper isn't worth the pixels used to display it on a screen. I don't think so. You are using an out of date browser. There are several books out there written about the topic. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. (February 2002). As I have lung cancer and just recently was diagnosed hypothyroidI am very interested as to what you have to say about this connection.your personal insight and any books, websites would be appreciated.you may email me if you prefer. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. Brit Med J 1978, 1:210212. 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. Privacy Policy. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. This is a horrible disease that ravages the body. New Cholesterol Drug Guaranteed to Prematurely Kil Beware the Walgreens travel vaccination scam. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. The Dangers of Tylenol: Is it Time to for the FDA Chile: Psychiatrist Leads Crusade To Legalize Mari 13 Things Sure To Slow Down Your Metabolism. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. I have posted the link, so you can see if it has any merit. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Also, what is oxidised stress??? An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. But what can be done for patients who are at low is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Log In. Another recently approved drug is tepotinib (Tepmetko). (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? All the more reason to prescribe T3, I say! Cookie Notice Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Acta Endocrinol 1988, 118:460464. You may not notice signs or symptoms of the disease. Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Is that what releases free radicals? Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. I have been reading Izabella Wentz. Iodine - and the lack of it - is implicated in breast cancer, after all. Endocrinol. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. rocket fuel, pesticides, fluoride, which induce low thyroid function. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Researchers are currently studying. Is Drug-Based Medicine a Form of Human Sacrifice? Share your experience, learn from others. Hypothyroidism can also lead to swelling of the tongue, hoarse voice, and sleep apnea. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Clin Cancer Res 2011, 30:77. Tokushima J Exp Med 1991, 38:2535. So I will leave it as a simple thank you for passing this along. I have no further scientific evidence. It was the therapist that I went to that referred me to a specialist who ran the correct tests. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. It is worth reading. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. undefined will no longer be visible to you including posts, replies, and photos. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Here members can share stories, find important information and learn from the experiences of others like themselves. Clin Cancer Res 2011, 30:77. Patient characteristics. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism. Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. However, that information will still be included in details such as numbers of replies. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). 2004 Jun;9(2):157-79. What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. Or that it was the many years of not being diagnosed with hypothyroidism, courtesy of daft blood test ranges, before finally tipping a TSH over 5 (or even 10) before treatment is commenced, by which time the damage is done. [13] Hollowell JG, Staehling NW, Flanders WD, et al. I wish I could say that my story was atypical. 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View the data on our Hypothyroidism Research page. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Different strokes for different folks for sure! [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Nah, I would give this much credence. The relationship between levothyroxine use and cancer risk is largely underdetermined. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. Just go on one of the thyroid sites and read the stories. Overtreatment, of course, is the hallmark danger of overdiagnosis. Endocrinology 2008, 149:22412250. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Salt, Sugar, Fat: 15 Shocking Facts From the Book Dear Doctor, Do You Really Know What Vaccines Cont Colloidal Gold: Discover the Benefits and Wonders, Scientists Explain Why HPV Vaccines Are Unsafe. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. I discovered this article published in Wakeup World. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Metab.87 (2): 48999. Heart problems. JavaScript is disabled. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. LOL. Brit Med J 1978, 1:210212. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. PLoSone 2011, 11:e27547. Link posted. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. J Exp Biol 2010, 213:28992911. It does not necessarily imply one thing caused the other. Due to excessive bot signups along with nefarious actors we are limiting forum registration. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). PLoSone 2011, 11:e27547. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. Even in the mildest form, hypothyroidism affects the heart. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? Correlation is NOT causation. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. For a better experience, please enable JavaScript in your browser before proceeding. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. Hashimoto's disease progresses slowly over the years. This discussion has been closed to comments. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. Why not simply call it selenium deficiency? SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation.

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