morosil blood orange extract drug interactions

morosil blood orange extract drug interactions

Sure, youve probably heard of omega-3s, vitamin D, and others. Antioxidant Efficacy of a Standardized Red Orange (. Some, Read More Does Milk Whiten Teeth?Continue, Your email address will not be published. Warfarin functions by interacting with vitamin K in the body, and vitamin K intake should therefore be consistent in order for the drug to work optimally. Epub 2021 Jun 2. Overall, the Moro blood orange standardized extract combined with diet and exercise was shown to be safe and well-tolerated. MOROSIL is a standardized solid extract obtained only from the juice of a unique cultivar of Moro red oranges (Citrus sinensis (L.) Osbeck). Blood orange extract is a natural ingredient that has many benefits for the skin. Do fat burning gummies work? According to research, Morosil has been proven to be effective. 03325100877 DEVELOPED WITH PASSION BYMCA, Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola - Belpasso (CT) - Italy +39 095 7086560 | info@bionap.com | www.bionap.com, COPYRIGHT 2021 BIONAP S.R.L. One way to manage your calorie intake and shed pounds is to. This is where antioxidants come in. Great Value Tilapia is a popular choice for aquaculture due to its fast growth rate and ability, Read More Where Does Great Value Tilapia Come From?Continue, You can freeze king cake! Morosil is an extract of the Moro variety of blood orange. It may be an issue if you suffer from acid reflux diseases. Blood orange extract is extracted from the peel of the fruit, which contains a lot of antioxidants . If the cheese is tightly wrapped in foil or plastic wrap, it will last on the longer end of the spectrum. More serious side effects are rare but could include allergic reactions or liver damage. Morosil is able to affect the metabolism of adipocytes and reduce fat accumulation on the body due to the synergistic mechanism related to the pool of biophenols contained in the enriched blood orange extract. In todays article, we will dive into what Morosil is, what the benefits are, how it works, and if you should consider adding it to your daily routine, which should include a sensible diet and exercise. bath and body works waikiki beach coconut hand sanitizer; fidelity 1099-r federal id number; folding rollaway bed with mattress What is Morosil? But as far as promoting any substantial weight loss as it promises dont count on it. The Moro orange has been found to contain active compounds that may control fat accumulation, leading Bionap to produce MOROSIL, a Moro extract designed to control weight naturally. Examples include diphenhydramine, known as Benadryl, and fexofenadine, known as Allegra. Application: Weight Management. What does Morosil blood orange extract do? : TWE21145 3) brand : TIANWEI 4) Latin name : Citrus Reticulata Blanco (orange flavour extract) 5) Characteristic: powder 6) Product Specification: Orange flavour extract is mainly a nutritious food extracted from oranges. Morosil Blood Orange Extract; More >> Meat, Poultry & Seafood. Morosil is also a good source of vitamins A and C, which are important for overall health. Bionap is headquartered not far from Mt. Morosil is made by the Italian company Bionap S.R.L., a dynamic and innovative group which since 1997 has produced standardized extracts obtained from plants and fruits growing in the areas surrounding Mt. ITS Science & Medical (Singapore) Interscience (Malaysia) Egg Powder; Instant Fruit Powders; More >> > Nutraceutical> Blood Orange Extract. Vitamin C, flavonoids, hydroxycinnamic acids, and anthocyanins, which have antioxidant properties, are all abundant in moro oranges. Morosil is an extract of the Moro variety of blood orange. The jury is still out on whether milk can really help whiten teeth. These oranges have a higher range of antioxidants and compounds that support weight loss and are heart-healthy. Morosil is a blood orange extract that is sourced from Moro orange juice, grown in Sicily. Start your wellness journey and sign up for our newsletters or follow us on social media. The moro blood orange has the deepest color red of any varieties available. This can lead to regurgitation or heartburn (x). Supplements have been garnering a lot of attention in recent years. She believes that food should be accessible to everyone, regardless of their budget or dietary restrictions. The researchers conclude that "supplementation with the standardized extract may significantly contribute as a complementary strategy in weight management programs." References . The following qualities of Morosil can help you reach your weight goals: Although mostly used as an aid in weight loss, Morosil used in a pre-workout or protein blend can also have a positive effect on your workouts when taken before you hit the gym. Little wonder, then, that prenatal supplement regimens include folic acid (a form of folate) (x). Like any other supplement, it is still important to abide by any advice given by a legitimate medical professional. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). While there is some evidence to support these claims, the majority of it is in the form of animal studies or small human studies. For example, grapefruit juice can lower the levels of enzymes in your liver responsible for breaking down medications. In addition, Morosil regulates your appetite and boosts your exercise routine. government site. Vitamin A helps maintain healthy skin (epithelial) tissue. SCIENTIFIC INVESTIGATIONS OF MOROSIL EFFECT Blood Orange Benefits Rich in Vitamin C You can add it to a beverage or add it to whatever youre baking or cooking. Application: Weight Management. Capsimax is a capsicum extract in a bead technology to avoid oral and gastric burning. Those who dont get enough vitamin A may be more susceptible to dry skin, dry eyes and throat and chest infections (x, x). You should not take fexofenadine with orange, apple or grapefruit juice, because they decrease the medication's bioavailabilty, according to Colorado State University Extension. However, this highly depends on how it is stored. In this study, we investigated in vitro, the antioxidant and anti-adipogenic activities of Morosil , a standardised extract of Moro blood oranges. Half of the adults also took 400mg of Morosil, Compared to the placebo group, those taking Morosil, So I know weve mentioned anthocyanins quite a bit throughout this article, so lets talk about what exactly they are and why theyre important, especially in Morosil. The most likely way that Morosil causes weight loss is by reducing your appetite. They belong to a wider class of plant-based compounds known as flavonoids. For informational purposes only. The vitamin C in Morosil also promotes muscle protection during exercise. It provides a much better supply of fat-burning compounds than comparable weight management supplements. There are references to the blood orange in paintings, mosaics, and even poetry. To thaw, simply leave the cake out at room temperature for several hours, or overnight. Also, the calcium and phosphorus in milk help to strengthen tooth enamel and make it more resistant to staining. Moro oranges are high in vitamin C, flavonoids, hydroxycinnamic acids, and anthocyanins that contain antioxidant properties. Buy NatureCity True-Slim 400mg Morosil Weight and Fat Loss Supplement Helps Reduce Fat Accumulation 30 Veggie Capsules on Amazon.com FREE SHIPPING on qualified orders Amazon.com: NatureCity True-Slim 400mg Morosil Weight and Fat Loss Supplement Helps Reduce Fat Accumulation 30 Veggie Capsules : Health & Household Skip to main content .us Hello Morosil is a blood orange extract that is sourced from Moro orange juice, grown in Sicily. The company explains how the extract works. But if youre taking certain medications, you may need to avoid certain types of fruits or vegetables because of how they interact with medications. Its a star player in the world of fitness and health supplements. Blood orange juice inhibits fat accumulation in mice. Moro juice; obesity; red orange; weight management. It is claimed to have numerous health benefits, including weight loss, improved circulation, and reduced cholesterol levels. All antioxidants contain a single electronic charge which pairs up with the free radicals prematurely dropped charge, thereby neutralizing the free radical altogether. Pera orange (Citrus sinensis) and Moro orange (Citrus sinensis (L.) Osbeck) juices attenuate left ventricular dysfunction and oxidative stress and improve myocardial energy metabolism in acute doxorubicin-induced cardiotoxicity in rats. Don't just lose weight, keep it off with Mdrive Lean. 1 Comment. Blood levels of an interacting drug may rise, leading to toxicity. MOROSIL Sicilian red orange (Moro variety) fruit . Morosil is a branded extract of a cultivar of blood oranges ( Citrus sinensis) indigenous to the southeastern regions of Sicily. No oranges do not interact with the drugs and grapefruit only interact with the statin drugs and increase the amount of the drug in your system. Blood orange supplements can be found in powders, capsules and tablets. Garca-Cordero J, Sierra-Cinos JL, Seguido MA, Gonzlez-Rmila S, Mateos R, Bravo-Clemente L, Sarri B. Yarhosseini F, Darand M, Sangsefidi ZS, Mozaffari-Khosravi H, Hosseinzadeh M. Obes Sci Pract. One study found that Morosil increased energy expenditure in rats, meaning they burned more calories. A 2013 study examined the effects that blood orange juice had on mice. Moro Red Orange is the most colorful of the blood oranges. But what are antioxidants, and what purpose do they actually serve? Since oranges are rich in antioxidants, and other nutrients, they play a major role in facilitating hair growth. These antibiotics are used to inhibit the growth of bacterial and fungal infections. This study aimed to assess the efficacy of a blood orange Citrus sinensis standardized extract from Moro cultivar, on weight loss in overweight but otherwise healthy individuals. Morosil blood orange extract is a natural product made from the peel of blood oranges. This influences your lipid metabolism, which breaks down fat and generates energy. Warfarin is a very important and effective drug used to decrease the bloods tendency to form clots. Moro orange is a cultivar of red orange, particularly rich in active compounds such as anthocyanins, hydroxycinnamic acids, flavone glycosides and ascorbic acid, which displays anti-obesity effects in in vitro and in vivo studies. Limit caffeine. morosil sicilian blood orange extract. Moro is the most pigmented blood orange. Morosil is the dry extract obtained from the juice of moro oranges, a variety of the fruit that has a red color and is common in Italy. In this clinical study, the effect of a Moro juice extract (Morosil(), 400 mg/die) supplementation was evaluated in overweight healthy human volunteers for 12 weeks. 60 Veg Capsules. Applies to: diltiazem. With a rise in wellness-focused products and active lifestyles, now is a great time to learn about supplements and their ingredients. Free Shipping $70+ or when you Subscribe. MOROSIL is a standardized extract obtained from the juice of a unique cultivar of Moro red oranges (Citrus sinensis (L.) Osbeck). Magalhes ML, de Sousa RV, Miranda JR, Konig IFM, Wouters F, Souza FR, Simo SD, da Silva Lunguinho A, Nelson DL, das Graas Cardoso M. J Sci Food Agric. According to research, Morosil has been proven to be effective. Antioxidant Support. Edna in eastern Sicily. The Moro orange has been found to contain active compounds that may control fat accumulation, leading Bionap to produce MOROSIL, a Moro extract designed to control weight naturally. These include weight loss, improved cholesterol levels, and reduced inflammation. Another study found that Morosil decreased hunger in humans when compared to a placebo. It is here that Bionap cultivates many of the fruits and plants used in its products including the unique Moro oranges used to make Morosil, Help users lose excess pounds or maintain a healthy body weight, Help reduce the accumulation of fat in areas like the waist and hips, According to preliminary human research, supplementing overweight but otherwise healthy participants with 400 mg of a Moro blood orange standardized extract (Morosil, Adults between the age of 20 and 65 (overweight, but otherwise healthy) were given a reduced calorie diet and exercise advice to follow for 6 months. These antioxidants and other active ingredients protect the body from the effects of free radicals. A systematic review and meta-analysis of randomized controlled trials. Thanks to the synergistic mechanism related to the pool of biophenols contained in enriched blood orange extract, MOROSIL may be used for weight control and, acting on fat accumulation, it can indirectly been used to reduce the risk of onset and chronicity of cardiovascular related problems. Consult your physician for any health problems. morosil blood orange extract drug interactions . Morosil is a blood orange extract that is used as a dietary supplement. Read More Can Oat Milk Be Frozen?Continue, There are a few possible explanations for why crab legs might give you diarrhea. Morosils increasing popularity and use in wellness products is a testament to that. Finally, Morosil may also help you lose weight by increasing the amount of fat you burn. Theyre rich in vitamin C, which can boost your immune system, and are a good source of folate and beta-carotene. Most recipes call for sweeter adaptations of the blood orange. Targets waist and hip fat: Having fat buildup around your waist is unhealthy. What Is Morosil? The https:// ensures that you are connecting to the It also regulates your cholesterol levels, boosts your immune function, and aids in absorbing ironall essentials to maximizing your fitness regimen. Aromor Yeast Extract. Blood orange powder produced by Runherb INC is spray-dried from freshly squeezed juice from fresh blood oranges. Moro Red Orange Extract. It also promotes the daily replenishment of skin cells in order to create a barrier to topical infections (x). Vitamin A is a micronutrient that our bodies dont produce naturally. We'll assume you're ok with this, but you can opt-out if you wish. Morosil is a blood orange extract that is sourced from Moro orange juice, grown in Sicily. Blood Orange Blood oranges, also called pigmented or moro oranges, are similar to regular oranges, except the fruit is colored a deep red. Mdrive Lean combines Morosil with whey protein, The Importance of Mobility for Men (Plus 4 Exercises to Improve Mobility). In this study, we investigated in vitro, the antioxidant and anti-adipogenic activities of Morosil , a standardised extract of Moro blood oranges. August 30, 2022 0 comments suite collection . Adding a supplement to your dietary regimen or even just experimenting with fresh blood oranges in the kitchen may be a worthwhile consideration! While more high-quality, long-duration research is needed, there is evidence that bitter orange extract helps with weight loss. PhenQ Best appetite suppressant overall. Some proponents of using blood orange extract for weight loss also suggest that it can help reduce appetite and cravings, as well as promote a healthy digestive system. Thanks to the synergistic mechanism related to the pool of biophenols contained in enriched blood orange extract, MOROSIL may be used for weight control and, acting on fat accumulation. Antioxidants generate quite a bit of buzz for their health-promoting properties. The product is also occasionally taken as a solid functional food or instantaneous drink. Mdrive Lean combines Morosil with whey protein to fuel your body's weight loss process while helping you build lean muscle. One of Sicilys most popular salads, however, consists of blood orange and fennel bulbs. Morosil is a standardized solid extract derived from the juice of a unique cultivar of Moro red oranges (Citrus sinensis (L.) Osbeck). SCIENCE & MEDICAL. However, because they still carry an electronic charge, these free radicals can react with and damage other molecules (including our DNA) (x). Made In U.S.A. by a registered cGMP manufacturer and encapsulated in Non GMO Vegetable capsules. MeSH Become a pro gambler with new ideas. Just like a classic navel orange, blood oranges can be squeezed for a fresh morning juice, sliced into snacks, tossed into fruit and vegetable salads, and used as an ingredient in zillions of recipes for desserts and savory dishes. morosil blood orange extract drug interactions morosil blood orange extract drug interactions. So I know weve mentioned anthocyanins quite a bit throughout this article, so lets talk about what exactly they are and why theyre important, especially in Morosil! Great Value Tilapia is a type of fish that is found in fresh water lakes and rivers. The Phytocomplex contained in the Moro juice have been shown to possess a high content of anthocyanin with an important activity against fat accumulation and obesity, which has not been seen in other orange varieties. London: Pharmaceutical Press. Thats because blood oranges are not regular oranges that have been artificially dyed, as some people might assume upon first encountering the deeply colored fruit. A recent in vivo trial, published in the prestigious International Journal of Obesity, showed that Moro extract obtained from . Moro red oranges are the most colorful of the blood oranges due to their high content of anthocyanins. It is claimed to have numerous health benefits, including weight loss, improved circulation, and reduced cholesterol levels. Blood orange extract is extracted from the blood orange fruits. Morosil is a blood orange extract that is sourced from Moro orange juice, grown in Sicily. By Food and Life Lover February 14, 2023. More specifically, it may have the following effects on the body: Does Moro blood orange extract help you lose weight? Morosil is a blood orange extract clinically shown to minimize fat accumulation. Your email address will not be published. Experts say that one of the key substances within the Moro orange is anthocyanins, which is responsible for the beneficial effects that the red-orange extract has on the body. Morosil is typically available as 400 500 mg capsules, tablets, or granules. Maryann is a registered dietitian & wellness expert who's helped thousands achieve their nutrition and wellness goals while still being able to live their lives and enjoy the foods they love! Diuretics are used to help reduce the amount of fluids in your body. Blood orange supplements and extracts may offer many health benefits. Clipboard, Search History, and several other advanced features are temporarily unavailable. Morosil contains vitamins and minerals that are good for your health. Supplements in Review Says. Avoid using morosil as a stand-alone supplement. Morislim is made with Morosil, an extract derived from the juice of Sicilian Moro red oranges harvested from orchards in Italy. How Much Water Does A Blood Orange Tree Need? Studies show it decreases the risk of birth defects such as facial clefts, congenital heart disease, urinary tract anomalies and even some pediatric cancers. Blood oranges are high in potassium, with 260 milligrams in one medium fruit. You can find oat milk in most grocery stores, but it can be expensive. Blood oranges provide only a modest amount of folate, but blood orange supplements may contain a higher concentration folic acid (x). Blood levels of an interacting drug may rise, leading to toxicity. It speeds metabolization of some, and slows it for others. Color of the orange flesh is an intense violet-red, at times almost black, due to the high content of anthocyanins. Oat milk is high in fiber and vitamins A and D. Its also low in calories and fat. Overview. Thanks to scientific advancements and research, Morosil, In todays article, we will dive into what Morosil, Numerous bioactive compounds found in Morosil, These nutritional compounds are believed to be responsible for the weight management properties exhibited by Morosil, Additionally, recent studies on humans and animals have discovered that flavonoids, particularly the abundantly present anthocyanin in Morosil, Bionap is headquartered not far from Mt. This also means not drinking juice made from blood oranges while taking this type of antihistamine. official website and that any information you provide is encrypted Foods. sharing sensitive information, make sure youre on a federal However, like all supplements, it is important to be aware of the potential side effects before taking it. The company explains how the extract works. Also known as vitamin B9, folate is a vital nutrient, especially during pregnancy. MyPlate - Blood Oranges and The Negative Interaction With Medicatio How fruit juice interacts with common medicines. Moro oranges are the most colorful of the blood oranges. Leanbean Best non-caffeinated appetite suppressant. Results showed that Moro juice extract intake was able to induce a significant reduction in body mass index (BMI) after 4 weeks of treatment (p < 0.05). During adipocyte differentiation, 3T3-L1 cells were treated with concentrations of extract containing 2.5, 5, 10, 25 M of anthocyanins. This site needs JavaScript to work properly. Morosil, a standardised solid extract obtained only from the juice of Moro blood oranges is a natural ingredient developed for the management of overweight and in the prevention of obesity. This effect has been seen in both animal and human studies. Regular Consumption of Green Coffee Phenol, Oat -Glucan and Green Coffee Phenol/Oat -Glucan Supplements Does Not Change Body Composition in Subjects with Overweight and Obesity. A recent study has found that a Sicilian Moro orange extract, when combined with a sensible diet and exercise, may provide incremental weight and fat loss benefits - and help reduce the . They contain the powerful antioxidant anthocyanin, which helps neutralize free radicals and prevent cellular damage. Thanks to the synergistic mechanism related to the pool of biophenols contained in enriched blood orange extract, MOROSIL may be used for weight control and, acting on fat accumulation, it can indirectly been used to reduce the risk of onset and chronicity of cardiovascular related problems. Morosil is a blood orange extract clinically shown to minimize fat accumulation. MOROSIL Sicilian red orange (Moro variety) fruit . The soil in this region is very rich, in fact, it is considered an optimal area to grow the Moro orange because large diurnal temperature fluctuations (hot days, cold nights) cause an intense red pigmentation in the orange flesh. WITHOUT DIET RESTRICTION AND PHYSICAL ACTIVITY, clicking on "Send" you accept our privacy policy, Contrada Fureria Zona Industriale Ovest Supports Cholesterol Regulation. Thats because it is extracted specifically from the Moro blood orange. The Phytocomplex contained in Moro juice, unlike other orange varieties, have been shown to possess an high content of anthocyanins with an important activity against fat accumulation. Curcumin Su https://pubmed.ncbi.nlm.nih.gov/25588369/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838101/. Therefore, it is important to speak with a healthcare professional before taking Morosil or any other supplement. If you are experiencing health issues prior to taking supplements, be sure to speak with a doctor. Within our cells, numerous molecules interact with each other. Blood oranges, a type of citrus fruit, can interact with a number of medications. While its not as common as other supplements and wellness ingredients, its one of the more effective ones out there. FOIA MOROSIL supplementation showed to induce a significant reduction of body weight, BMI, waist and hip circumference after a period of treatment of 12 weeks. What Is Morosil Sicilian Blood Orange Extract? The flavor is stronger and the aroma is intense. Blood oranges contain high amounts of potassium, and regular consumption can be problematic for people taking beta-blockers. 8600 Rockville Pike Vitamin C plays a role in strengthening and boosting the immune system. Clinical trials have shown its capacity to support weight loss. These products are not intended to diagnose, treat, cure or prevent any disease. The intake of Morosil has several side effects. *These statements have not been evaluated by the Food and Drug Administration. Moreover, it has been demonstrated that pre-adipocyte proliferation and differentiation can be controlled by redox metabolism suggesting that ROS are involved in adipocyte differentiation. MOROSIL Sicilian red orange (Moro variety) fruit . 60 Vegetable Capsules / 1 Capsule per Serving / Once Daily. of signs you need emergency medical attention or call 911. Interestingly, no other citrus fruit contains anthocyanin. A popular way to use blood orange supplements is to mix it into green tea. Even one blood orange provides most of the recommended amount of vitamin C for most people (x). When taking any dietary supplement, it is highly advised that you consult your physician. Results showed that Moro juice extract intake was able to induce a significant reduction in body mass index (BMI) after 4 weeks of treatment (p < 0.05). Bookshelf Moreover, in subjects treated with Moro extract, body weight, BMI, waist and hip circumference were significantly different from the placebo group (p < 0.05). Dihydrotestosterone (DHT) the most powerful and misunderstood male hormone? Morosil is an extract of the Moro variety of blood orange. This website uses cookies to improve your experience. Careers. These nutritional compounds are believed to be responsible for the weight management properties exhibited by Morosil. A diet high in saturated fats, red meat, and fast foods tend to promote fatty plaques in your blood vessels, which can increase the risk of heart disease and stroke. 2023 Jan 23;9(1):42-58. doi: 10.1002/osp4.651. It can also cause headaches and dizziness. Pharmaceutical Journal 293 (7831): 369-372. More Information. Federal government websites often end in .gov or .mil. However, some people believe that the antioxidants and flavonoids found in blood oranges can help boost metabolism and promote fat burning. LEIBER. Morosil is a weight loss supplement that is claimed to help you lose weight by reducing your appetite, boosting your metabolism, and increasing the amount of fat you burn. Bitter orange appears to promote fat loss by boosting metabolism. MOROSIL contains active substances (flavonoids and others) , able to affect the metabolism of adipocytes, the primary site of energy storage and accumulation of lipids during nutritional excess in the body. Immune Support Visit the Anew Vita Store 34 ratings Amazon's Choice in Blended Vitamin & Mineral Supplements by Anew Vita Price: $35.99 ($0.60 / Count) About this item Chemistry and Pharmacology of Citrus sinensis. Thanks to scientific advancements and research, Morosil is becoming increasingly popular in the wellness community. Made from Sicilian moro oranges, Morosil may help you lose some excess pounds, and reduce the accumulation of fat in areas like the waist and hips in conjunctionwith diet and exercise. Taking bitter orange along with diabetes medications might cause your blood sugar to become too low. Morosil works best as part of a collective of other ingredients, as seen in common weight loss and wellness supplements. An increase in heartburn as Morosil is highly acidic. Etna, the main volcano in the Mediterranean area. Moro is the most pigmented blood orange. LEARN MORE. If you're looking for a healthy way of losing weight, Morosil supplements may be the solution. World Health Organisation. Morosil is also high in antioxidants and vitamin C, which are thought to be beneficial for overall health. Intermittent fasting is where you have a set window during the day when you can eat. *These statements have not been evaluated by the Food and Drug Administration. More Information. NO Preservatives or Additives. Published. Han HS, Chung KS, Shin YK, Yu JS, Kang SH, Lee SH, Lee KT. The site is secure. Grapefruit interacts with many drugs. 24 April 2017. While the body relies on acute inflammation to fight infections, heal wounds and repair tissue damage, chronic inflammation is another story. MOROSIL is a standardized solid extract obtained only from the juice of a unique cultivar of Moro red oranges (Citrus sinensis (L.) Osbeck). The company explains how the extract works. Also known as ascorbic acid or citric acid, vitamin C helps cells produce a molecule called adenosine triphosphate (ATP for short). Another review of 13 studies concluded that citrus fruits and their extracts may be effective in losing weight ( 9 ). Uncategorized. Eos Vanilla Cashmere Perfume, Is this an emergency? It contains anthocyanin cyanidin-3-O-glucoside, which is good at reducing inflammation. This means that it may cause certain medications to pass from the GI tract into the bloodstream faster than normal, raising the amount of medication in your bloodstream, which can be potentially dangerous.

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morosil blood orange extract drug interactions